Detecting the Migration and Accumulation of Macrophages in An Acute Rejection Model of Heart-lung Transplantation in Rats by in vivo MRI Using A New Nano-sized Iron Oxide Particle
نویسندگان
چکیده
H. Zhang, Q. Ye, C-L. Chen, K. Hitchens, W-Y. Hsieh, L. Liu, Y. Wu, L. Foley, H-H. Shen, J. Wang, and C. Ho NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA, United States, Biomedical Engineering Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan, Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan
منابع مشابه
Detection of macrophage accumulation after heart transplantation in a rat using a novel nano-sized iron oxide particle with high relaxivity
INTRODUCTION The gold standard for detecting organ rejection after transplantation is biopsy, which is not only invasive but also prone to sampling errors. We have been developing and optimizing MRI techniques to assess organ rejection after transplantation by monitoring the accumulation of immune cells at the rejection site using various iron-oxide-based contrast agents [1-3]. There are two sc...
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In vivo cell tracking by MRI can provide means to observe biological processes and monitor cell therapy directly. Immune cells, e.g., macrophages, play crucial roles in many pathophysiological processes, including organ rejection, inflammation, autoimmune diseases, cancer, atherosclerotic plaque formation, numerous neurological disorders, etc. The current gold standard for diagnosing and stagin...
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BACKGROUND Current immunosuppressive therapy after heart transplantation either generally suppresses the recipient's entire immune system or is mainly targeting T-lymphocytes. Monocytes/macrophages are recognized as a hallmark of acute allograft rejection, but the roles that they play are not well characterized in vivo, because the tools for accessing in situ macrophage infiltration are lacking...
متن کاملMacrophage accumulation associated with rat cardiac allograft rejection detected by magnetic resonance imaging with ultrasmall superparamagnetic iron oxide particles.
BACKGROUND Acute cardiac allograft rejection continues to be the cause of graft loss and contributes to the morbidity and mortality after cardiac transplantation. In this study, we report a new method for detecting organ rejection in transplantation with an MR-based technique using dextran-coated ultrasmall superparamagnetic iron oxide (USPIO) particles. These particles ( approximately 27 nm in...
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Background—Current immunosuppressive therapy after heart transplantation either generally suppresses the recipient’s entire immune system or is mainly targeting T-lymphocytes. Monocytes/macrophages are recognized as a hallmark of acute allograft rejection, but the roles that they play are not well characterized in vivo, because the tools for accessing in-situ macrophage infiltration are lacking...
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